Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

Fan, Xue-Ru, He, Ye, Wang, Yin-Shan, ..., -, Mothersill, David and et al., - (2025) Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia. Communications Biology, 8 (1). ISSN 23993642

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Abstract

We explore neurodevelopmental heterogeneity in Autism Spectrum Disorder (ASD) through normative modeling of cross-cultural cohorts. By leveraging large-scale datasets from Autism Brain Imaging Data Exchange (ABIDE) and China Autism Brain Imaging Consortium (CABIC), our model identifies two ASD subgroups with distinct brain morphological abnormalities: subgroup “L” is characterized by generally smaller brain region volumes and higher rates of abnormality, while subgroup “H” exhibits larger volumes with less pronounced deviations in specific areas. Key areas, such as the isthmus cingulate and transverse temporal gyrus, were identified as critical for subgroup differentiation and ASD trait correlations. In subgroup H, the regional volume of the isthmus cingulate cortex showed a direct correlation with individuals’ autistic mannerisms, potentially corresponding to its slower post-peak volumetric declines during development. These findings offer insights into the biological mechanisms underlying ASD and support the advancement of subgroup-driven precision clinical practices.

Item Type:	Article
Uncontrolled Keywords:	adolescent; autism; brain; child; China; diagnostic imaging; female; human; male; nuclear magnetic resonance imaging; pathology; preschool child
Subjects:	B Philosophy. Psychology. Religion > Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry H Social Sciences > HQ The family. Marriage. Woman > Children > Child Development R Medicine > Diseases > Disabilities > Developmental disabilities
Divisions:	School of Business and Social Sciences > Staff Research and Publications
Depositing User:	Tamara Malone
Date Deposited:	24 Oct 2025 10:51
Last Modified:	24 Oct 2025 10:51
URI:	https://norma.ncirl.ie/id/eprint/8866

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