MRI-Based Early Detection and Classification of Alzheimer's Disease with Grad-CAM Explainability

Agarwal, Pratham, Saini, Pranshu, Ghosh, Debjani, Kumar, Vimal and Gupta, Punit (2025) MRI-Based Early Detection and Classification of Alzheimer's Disease with Grad-CAM Explainability. In: 2025 Seventeenth International Conference on Contemporary Computing (IC3). IEEE, Noida, India. ISBN 979-833155901-4

Full text not available from this repository.

Abstract

Alzheimer's disease is a progressive neurodegenerative disorder that profoundly affects memory and cognitive abilities. For prompt intervention and care planning, an accurate and early-stage classification is essential. This research utilizes a publicly available MRI dataset to support the classification and analysis process. From conventional machine learning models like K-Nearest Neighbors (KNN) and Ensemble methods, to sophisticated deep learning techniques like a custom Dual-Branch Convolutional Neural Network (CNN) and a fine-tuned CNN model, this study offers a thorough assessment of several classification approaches. Among the conventional models, the CNN with Fine-Tuning performed the best in classification with F1-score, recall and accuracy of 96%, 94% and 95% respectively, followed by the KNN. To evaluate alignment with medically relevant brain regions and interpret model predictions, Grad-CAM heatmap visualizations were utilized. The results highlight how crucial it is for clinical decision support systems to diagnose Alzheimer's disease to be both accurate and interpretable.

Item Type:	Book Section
Uncontrolled Keywords:	Alzheimer's Disease; Convolutional Neural Network (CNN); Deep Learning; Explainability; Grad-CAM; KNN; MRI; Random Forest
Subjects:	R Medicine > RB Pathology R Medicine > Diseases > Brain - Diseases > Dementia > Senile dementia > Alzheimer's disease R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry > Neurology. Diseases of the Nervous System. > Psychoses > Dementia > Senile dementia > Alzheimer's disease Q Science > Q Science (General) > Self-organizing systems. Conscious automata > Machine learning
Divisions:	School of Computing > Staff Research and Publications
Depositing User:	Tamara Malone
Date Deposited:	01 Apr 2026 10:33
Last Modified:	01 Apr 2026 10:33
URI:	https://norma.ncirl.ie/id/eprint/9280

Actions (login required)

View Item