A grid-based stochastic simulation of unitary and membrane Ca2+ currents in spherical cells

González-Vélez, Virginia and González-Vélez, Horacio (2005) A grid-based stochastic simulation of unitary and membrane Ca2+ currents in spherical cells. In: 18th IEEE Symposium on Computer-Based Medical Systems (CBMS'05). IEEE Computer Society, pp. 171-176. ISBN 0769523552

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Abstract

We present a stochastic simulation of L-type Ca2+ current assuming thousands of calcium channels on the membrane of a spherical cell. We propose a three-state Markov model to simulate the individual contribution of each channel. Rather than using a statistical approximation, we actually consider each individual channel transitions between states and evaluate the unitary channel current. We compare this aggregated unitary contributions with simulated whole cell currents, both in response to a depolarising voltage pulse. On the computational side, we have employed a parameter sweep, component based approach. Being embarrassingly parallel by design, we have parallelised it in a naive manner. We argue its possible extension using algorithmic skeletons. The results presented account for hours of processing time on a dedicated grid.

Item Type:	Book Section
Subjects:	Q Science > QA Mathematics > Electronic computers. Computer science T Technology > T Technology (General) > Information Technology > Electronic computers. Computer science
Divisions:	School of Computing > Staff Research and Publications
Depositing User:	Caoimhe Ní Mhaicín
Date Deposited:	27 Feb 2014 19:23
Last Modified:	29 Apr 2016 13:54
URI:	https://norma.ncirl.ie/id/eprint/945

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