Interleukin 6 predicts increased neural response during face processing in a sample of individuals with schizophrenia and healthy participants: A functional magnetic resonance imaging study

Mothersill, David, King, Sinead, Holleran, Laurena, Dauvermann, Maria, Patlola, Saahithh, Rokita, Karolina, McManus, Ross, Keynon, Marcus, McDonald, Colm, Hallahan, Brian, Corvin, Aiden, Morris, Derek, Kelly, John, McKernan, Declan and Donohoe, Gary (2021) Interleukin 6 predicts increased neural response during face processing in a sample of individuals with schizophrenia and healthy participants: A functional magnetic resonance imaging study. NeuroImage: Clinical, 32 (102851). pp. 1-8. ISSN 2213-1582

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Abstract

Background
Deficits in facial emotion recognition are a core feature of schizophrenia and predictive of functional outcome. Higher plasma levels of the cytokine interleukin 6 (IL-6) have recently been associated with poorer facial emotion recognition in individuals with schizophrenia and healthy participants, but the neural mechanisms affected remain poorly understood.

Methods
Forty-nine individuals with schizophrenia or schizoaffective disorder and 158 healthy participants were imaged using functional magnetic resonance imaging during a dynamic facial emotion recognition task. Plasma IL-6 was measured from blood samples taken outside the scanner. Multiple regression was used in statistical parametric mapping software to test whether higher plasma IL-6 predicted increased neural response during task performance.

Results
Higher plasma IL-6 predicted increased bilateral medial prefrontal response during neutral face processing compared to angry face processing in the total sample (N = 207, tmax = 5.67) and increased left insula response during angry face processing compared to neutral face processing (N = 207, tmax = 4.40) (p < 0.05, family-wise error corrected across the whole brain at the cluster level).

Conclusions
These findings suggest that higher peripheral IL-6 levels predict altered neural response within brain regions involved in social cognition and emotion during facial emotion recognition. This is consistent with recent neuroimaging research on IL-6 and suggesting a possible neural mechanism by which this cytokine might affect facial emotion recognition accuracy.

Item Type:	Article
Uncontrolled Keywords:	IL-6; Facial emotion recognition; fMRI; Schizophrenia
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry B Philosophy. Psychology. Religion > Psychology > Cognitive psychology
Divisions:	School of Business > Staff Research and Publications
Depositing User:	Clara Chan
Date Deposited:	10 Dec 2021 11:48
Last Modified:	10 Dec 2021 13:39
URI:	https://norma.ncirl.ie/id/eprint/5196

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