S20-02 - Follow up of schizophrenia gwas based on cognitive performance, high density eeg, and structural brain imaging

Donohoe, Gary, Rose, Emma Jane, Morris, Derek, Hargreaves, April, Gill, Michael and Corvin, Aiden (2011) S20-02 - Follow up of schizophrenia gwas based on cognitive performance, high density eeg, and structural brain imaging. European Psychiatry, 26 (1). p. 2083. ISSN 0924-9338

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Abstract

The advent of genome wide association studies have resulted in the identification of a number of novel genetic loci for schizophrenia and related disorders. Understanding the functional impact of these variants on brain structure and function is crucial to understand their role in disease pathology. We presents data based on our genetic and neuropsychological assessment of almost 700 patients and healthy participants for a number of these variants and replication of our findings in independent samples of almost 1500 cases and controls. Specifically, we will use this data to suggest that the risk associated with some genetics variants (e.g. NOS1) is being mediated by an influence on variation in intelligence and other cognitive phenotypes, while other risk variants (e.g. ZNF804A) delineate illness subtypes in which cognitive deficits are a less prominent feature.

Item Type:	Article
Subjects:	B Philosophy. Psychology. Religion > Psychology B Philosophy. Psychology. Religion > Psychology > Cognition
Divisions:	School of Business > Staff Research and Publications
Depositing User:	Caoimhe Ní Mhaicín
Date Deposited:	13 Apr 2016 09:44
Last Modified:	27 Mar 2018 09:20
URI:	https://norma.ncirl.ie/id/eprint/2156

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